ACP Journal Club. A 12-month, in-home exercise program delayed functional deterioration in Alzheimer disease.

An exercise and behavioral management program reduced functional dependence in Alzheimer disease.

I n t e r v e n t i o n Patient–caregiver dyads were allocated to the Reducing Disability in Alzheimer Disease (RDAD) program (n = 76) or routine medical care (n = 77). Patients and caregivers in the RDAD program received 12 one-hour sessions over 3 months. Patients were given aerobic, endurance, strength, balance, and flexibility training with the goal of ≥ 30 min/d of exercise. Caregivers wer...

Review: cholinesterase inhibitors may be effective in Alzheimer disease.

A community support program for dementia delayed but did not reduce institutionalization over 2 years.

P a t i e n t s 100 patients who were ≥ 65 years of age (mean age 79 y, 53% women), who were entitled to payments from the Social Insurance Institution for community care because they had dementia, and who lived at home with primary support from an informal caregiver. Exclusion criteria were other severe diseases that might lead to institutionalization or inability of caregivers to participate ...

Effects of exercise on spatial memory deficits induced by nucleus basalis magnocellularis lesions

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and short- term (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups 1) intact, 2) sham, 3) sham-Alzheimer 4) ...

The Memory Impairment Screen more accurately screened for Alzheimer disease than the 3-word memory test in older adults.

D e s c r i p t i o n o f t e s t s a n d d i a g n o s t i c s t a n d a r d The MIS is a 4-minute, 4-item delayed memory test assessing free and cued word recall. The conventional 3-word memory test is a delayed free recall memory task from the Mini-Mental State Examination (MMSE). The MIS and 3-word memory test were given on different days by different examiners. AD was diagnosed by clinical...